| 2. Round | 05/08/2000 | Newell's Old Boys | - | San Lorenzo | 1:0 | ||||
| 1. Round | 11/08/2000 | CA Los Andes | - | Newell's Old Boys | 1:1 |  |
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| 3. Round | 19/08/2000 | Chacarita Juniors | - | Newell's Old Boys | 0:2 | ||||
| 4. Round | 25/08/2000 | Newell's Old Boys | - | Boca Juniors | 1:3 | ||||
| 5. Round | 04/09/2000 | Argentinos Juniors | - | Newell's Old Boys | 0:1 | ||||
| 6. Round | 09/09/2000 | Newell's Old Boys | - | Unión de Santa Fe | 0:0 | ||||
| 8. Round | 23/09/2000 | Estudiantes | - | Newell's Old Boys | 0:0 | ||||
| 11. Round | 22/10/2000 | Newell's Old Boys | - | Almagro | 1:1 | ||||
| 12. Round | 27/10/2000 | Huracán | - | Newell's Old Boys | 2:0 | ||||
| 13. Round | 04/11/2000 | Newell's Old Boys | - | Lanús | 1:0 | ||||
| 14. Round | 10/11/2000 | River Plate | - | Newell's Old Boys | 2:0 | ||||
| 15. Round | 17/11/2000 | Newell's Old Boys | - | Vélez Sarsfield | 1:1 | |
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| 16. Round | 24/11/2000 | Colón de Santa Fe | - | Newell's Old Boys | 1:1 |  |
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| 17. Round | 02/12/2000 | Newell's Old Boys | - | Rosario Central | 0:0 | ||||
| 18. Round | 09/12/2000 | Independiente | - | Newell's Old Boys | 2:2 | ||||
| 19. Round | 16/12/2000 | Newell's Old Boys | - | Talleres de Córdoba | 1:0 |
Argentina