| 1. Round | 15/08/2021 | Adana Demirspor | - | Fenerbahçe | 0:1 | ||||
| 2. Round | 20/08/2021 | Kayserispor | - | Adana Demirspor | 1:1 | ||||
| 3. Round | 27/08/2021 | Adana Demirspor | - | Konyaspor | 1:1 | ||||
| 4. Round | 11/09/2021 | Fatih Karagümrük | - | Adana Demirspor | 4:0 | ||||
| 6. Round | 21/09/2021 | Beşiktaş | - | Adana Demirspor | 3:3 | ||||
| 8. Round | 01/10/2021 | Antalyaspor | - | Adana Demirspor | 1:2 | ||||
| 9. Round | 16/10/2021 | Adana Demirspor | - | Yeni Malatyaspor | 0:2 | ||||
| 17. Round | 18/12/2021 | Alanyaspor | - | Adana Demirspor | 1:3 | ||||
| 18. Round | 21/12/2021 | Adana Demirspor | - | Galatasaray | 2:0 | ||||
| 19. Round | 26/12/2021 | Göztepe | - | Adana Demirspor | 1:1 | ||||
| 20. Round | 10/01/2022 | Fenerbahçe | - | Adana Demirspor | 1:2 | ||||
| 23. Round | 22/01/2022 | Adana Demirspor | - | Fatih Karagümrük | 5:0 | ||||
| 24. Round | 06/02/2022 | Çaykur Rizespor | - | Adana Demirspor | 1:3 | ||||
| 25. Round | 14/02/2022 | Adana Demirspor | - | Beşiktaş | 1:1 | ||||
| 26. Round | 20/02/2022 | Gaziantep FK | - | Adana Demirspor | 0:3 | ||||
| 27. Round | 25/02/2022 | Adana Demirspor | - | Antalyaspor | 0:0 | ||||
| 28. Round | 04/03/2022 | Yeni Malatyaspor | - | Adana Demirspor | 1:0 | ||||
| 29. Round | 13/03/2022 | Adana Demirspor | - | Sivasspor | 2:3 |
Turkey