| 2. Round | 15/01/2022 | Municipal Grecia | - | CS Herediano | 1:1 |  |
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| 3. Round | 23/01/2022 | Santos de Guápiles | - | CS Herediano | 0:0 | ||||
| 4. Round | 04/02/2022 | CS Herediano | - | Deportivo Saprissa | 1:1 | ||||
| 6. Round | 15/02/2022 | CS Herediano | - | Sporting FC | 0:1 | ||||
| 1. Round | 18/02/2022 | CS Herediano | - | Jicaral | 1:1 | |
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| 7. Round | 20/02/2022 | CS Cartaginés | - | CS Herediano | 1:0 | ||||
| 8. Round | 27/02/2022 | CS Herediano | - | AD Guanacasteca | 1:2 | ||||
| 9. Round | 03/03/2022 | CS Herediano | - | LD Alajuelense | 1:1 | ||||
| 11. Round | 01/04/2022 | CS Herediano | - | Municipal Pérez Zeledón | 3:2 | ||||
| 14. Round | 17/04/2022 | CS Herediano | - | Santos de Guápiles | 3:0 | ||||
| 16. Round | 24/04/2022 | CS Herediano | - | AD San Carlos | 1:1 | ||||
| 19. Round | 04/05/2022 | AD Guanacasteca | - | CS Herediano | 0:1 |
Costa Rica