| 6. Round | 12/03/2022 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
| 7. Round | 21/03/2022 | General Caballero DJLM | - | Guaireña FC | 0:1 | ||||
| 13. Round | 30/04/2022 | General Caballero DJLM | - | Libertad | 0:1 | ||||
| 15. Round | 10/05/2022 | General Caballero DJLM | - | Sportivo Ameliano | 0:3 | ||||
| 17. Round | 22/05/2022 | General Caballero DJLM | - | Guaraní | 0:4 | ||||
| 18. Round | 12/06/2022 | Guaireña FC | - | General Caballero DJLM | 1:2 |  |
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| 19. Round | 17/06/2022 | General Caballero DJLM | - | Sol de América | 1:1 |
Paraguay