| 7. Round | 20/08/2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
| 8. Round | 27/08/2022 | General Caballero DJLM | - | Cerro Porteño | 1:1 | ||||
| 10. Round | 13/09/2022 | General Caballero DJLM | - | 12 de Octubre de Itauguá | 2:1 | ||||
| 11. Round | 17/09/2022 | Sol de América | - | General Caballero DJLM | 3:2 | ||||
| 13. Round | 24/09/2022 | General Caballero DJLM | - | Guaraní | 3:0 | ||||
| 14. Round | 02/10/2022 | Libertad | - | General Caballero DJLM | 1:0 |
Paraguay