| 5. Round | 18/08/2021 | Cruz Azul [U20] | - | CF Monterrey [U20] | 2:1 | ||||
| 6. Round | 21/08/2021 | CF Monterrey [U20] | - | Deportivo Guadalajara [U20] | 1:1 |  |
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| 7. Round | 27/08/2021 | Club Tijuana [U20] | - | CF Monterrey [U20] | 1:0 | ||||
| 8. Round | 11/09/2021 | Atlas Guadalajara [U20] | - | CF Monterrey [U20] | 3:1 | ||||
| 9. Round | 19/09/2021 | CF Monterrey [U20] | - | UANL Tigres [U20] | 0:1 | ||||
| 11. Round | 22/09/2021 | CF Monterrey [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 10. Round | 26/09/2021 | Santos Laguna [U20] | - | CF Monterrey [U20] | 4:1 | ||||
| 12. Round | 01/10/2021 | FC Juárez [U20] | - | CF Monterrey [U20] | 1:0 | ||||
| 13. Round | 16/10/2021 | CF Monterrey [U20] | - | Club León [U20] | 1:1 | |
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| 14. Round | 19/10/2021 | Gallos Blancos [U20] | - | CF Monterrey [U20] | 1:1 | ||||
| 15. Round | 23/10/2021 | CF Monterrey [U20] | - | Club Necaxa [U20] | 5:1 | |
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| 16. Round | 31/10/2021 | Atlético San Luis [U20] | - | CF Monterrey [U20] | 3:1 | ||||
| 17. Round | 06/11/2021 | CF América [U20] | - | CF Monterrey [U20] | 2:0 |
Mexico