| 1. Round | 08/01/2022 | CF Monterrey [U20] | - | Gallos Blancos [U20] | 0:0 | ||||
| 2. Round | 14/01/2022 | Club Necaxa [U20] | - | CF Monterrey [U20] | 1:1 | ||||
| 3. Round | 22/01/2022 | CF Monterrey [U20] | - | Cruz Azul [U20] | 2:2 | ||||
| 14. Round | 27/01/2022 | Pumas UNAM [U20] | - | CF Monterrey [U20] | 4:0 |  |
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| 5. Round | 12/02/2022 | CF Monterrey [U20] | - | FC Juárez [U20] | 1:0 |  |
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| 6. Round | 18/02/2022 | Puebla FC [U20] | - | CF Monterrey [U20] | 3:0 | |
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| 7. Round | 26/02/2022 | CF Monterrey [U20] | - | Atlético San Luis [U20] | 1:3 | ||||
| 8. Round | 01/03/2022 | Club León [U20] | - | CF Monterrey [U20] | 1:2 |  |
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| 9. Round | 05/03/2022 | CF Monterrey [U20] | - | CF América [U20] | 3:2 | |
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| 10. Round | 11/03/2022 | CF Monterrey [U20] | - | Mazatlán FC [U20] | 2:3 | ||||
| 11. Round | 19/03/2022 | UANL Tigres [U20] | - | CF Monterrey [U20] | 0:1 | ||||
| 13. Round | 26/03/2022 | CF Monterrey [U20] | - | Santos Laguna [U20] | 1:2 | |
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| 15. Round | 20/04/2022 | CF Monterrey [U20] | - | Atlas Guadalajara [U20] | 0:0 | ||||
| 16. Round | 23/04/2022 | CF Pachuca [U20] | - | CF Monterrey [U20] | 4:0 | ||||
| 17. Round | 30/04/2022 | CF Monterrey [U20] | - | Club Tijuana [U20] | 3:0 | |
Mexico