| 6. Round | 13/08/2021 | Rosario Central II | - | Independiente II | 3:1 | ||||
| 22. Round | 24/11/2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 | ||||
| 23. Round | 28/11/2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 24. Round | 03/12/2021 | Lanús II | - | Rosario Central II | 2:3 | ||||
| 25. Round | 10/12/2021 | Rosario Central II | - | Huracán II | 2:0 |
Argentina