| 1. Round | 16/07/2021 | Lanús II | - | Atlético Tucumán II | 0:0 | ||||
| 2. Round | 23/07/2021 | Atlético Tucumán II | - | Huracán II | 0:0 | ||||
| 3. Round | 27/07/2021 | Godoy Cruz II | - | Atlético Tucumán II | 2:2 | ||||
| 4. Round | 02/08/2021 | Atlético Tucumán II | - | Vélez Sarsfield II | 3:0 |  |
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| 5. Round | 06/08/2021 | Gimnasia de La Plata II | - | Atlético Tucumán II | 1:0 | ||||
| 6. Round | 14/08/2021 | Atlético Tucumán II | - | Aldosivi II | 3:2 | ||||
| 7. Round | 20/08/2021 | Sarmiento de Junín II | - | Atlético Tucumán II | 3:1 | ||||
| 8. Round | 24/08/2021 | Atlético Tucumán II | - | Independiente II | 0:0 | ||||
| 9. Round | 30/08/2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | ||||
| 15. Round | 08/10/2021 | Talleres de Córdoba II | - | Atlético Tucumán II | 1:1 | ||||
| 16. Round | 17/10/2021 | Atlético Tucumán II | - | Argentinos Juniors II | 0:0 | ||||
| 17. Round | 20/10/2021 | Estudiantes II | - | Atlético Tucumán II | 0:2 | ||||
| 19. Round | 29/10/2021 | Platense II | - | Atlético Tucumán II | 0:1 | ||||
| 20. Round | 05/11/2021 | Atlético Tucumán II | - | Racing Club II | 2:1 |
Argentina