| 30. Round | 05/02/2022 | Swindon Town | - | Exeter City | 1:2 | ||||
| 31. Round | 08/02/2022 | Exeter City | - | Leyton Orient | 1:0 | ||||
| 32. Round | 12/02/2022 | Bradford City | - | Exeter City | 0:1 |  |
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| 34. Round | 26/02/2022 | Bristol Rovers | - | Exeter City | 1:1 | ||||
| 35. Round | 04/03/2022 | Mansfield Town | - | Exeter City | 2:1 | ||||
| 23. Round | 08/03/2022 | Exeter City | - | Swindon Town | 3:1 | ||||
| 37. Round | 15/03/2022 | Exeter City | - | Crawley Town | 2:1 | ||||
| 38. Round | 19/03/2022 | Oldham Athletic | - | Exeter City | 0:2 | ||||
| 39. Round | 26/03/2022 | Exeter City | - | Stevenage FC | 2:1 | ||||
| 40. Round | 02/04/2022 | Newport County | - | Exeter City | 0:1 | ||||
| 33. Round | 26/04/2022 | Exeter City | - | Barrow AFC | 2:1 | |
England