| 1. Round | 07/07/2021 | PFC Ludogorets Razgrad | - | Shakhter Soligorsk | 1:0 |  |
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| 1. Round | 13/07/2021 | Shakhter Soligorsk | - | PFC Ludogorets Razgrad | 0:1 |  |
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| 2. Round | 21/07/2021 | NŠ Mura | - | PFC Ludogorets Razgrad | 0:0 | ||||
| 2. Round | 28/07/2021 | PFC Ludogorets Razgrad | - | NŠ Mura | 3:1 | |
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| 3. Round | 03/08/2021 | Olympiakos Piraeus | - | PFC Ludogorets Razgrad | 1:1 | |
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| 3. Round | 10/08/2021 | PFC Ludogorets Razgrad | - | Olympiakos Piraeus | 4:1 pso | |
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| Play-offs | 24/08/2021 | PFC Ludogorets Razgrad | - | Malmö FF | 2:1 |
Bulgaria