| 1. Round | 16/08/2021 | Yeni Malatyaspor | - | Trabzonspor | 1:5 | ||||
| 2. Round | 22/08/2021 | Göztepe | - | Yeni Malatyaspor | 0:1 | ||||
| 3. Round | 28/08/2021 | Yeni Malatyaspor | - | Gaziantep FK | 2:0 | ||||
| 4. Round | 11/09/2021 | Beşiktaş | - | Yeni Malatyaspor | 3:0 | ||||
| 9. Round | 16/10/2021 | Adana Demirspor | - | Yeni Malatyaspor | 0:2 | ||||
| 10. Round | 22/10/2021 | Yeni Malatyaspor | - | Altay Izmir | 2:1 | ||||
| 12. Round | 06/11/2021 | Yeni Malatyaspor | - | İstanbul Başakşehir | 1:3 |  |
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| 13. Round | 20/11/2021 | Giresunspor | - | Yeni Malatyaspor | 1:0 | ||||
| 14. Round | 28/11/2021 | Yeni Malatyaspor | - | Galatasaray | 0:0 |  |
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| 17. Round | 19/12/2021 | Çaykur Rizespor | - | Yeni Malatyaspor | 1:0 | ||||
| 18. Round | 23/12/2021 | Yeni Malatyaspor | - | Kayserispor | 2:2 | ||||
| 20. Round | 07/01/2022 | Trabzonspor | - | Yeni Malatyaspor | 1:0 | ||||
| 21. Round | 14/01/2022 | Yeni Malatyaspor | - | Göztepe | 1:2 |
Turkey