| 1. Round | 06/07/2021 | Mosta FC | - | Spartak Trnava | 3:2 | ||||
| 1. Round | 15/07/2021 | Spartak Trnava | - | Mosta FC | 2:0 | ||||
| 2. Round | 22/07/2021 | Spartak Trnava | - | Sepsi OSK | 0:0 | ||||
| 2. Round | 29/07/2021 | Sepsi OSK | - | Spartak Trnava | 3:4 pso |  |
|||
| 3. Round | 05/08/2021 | Spartak Trnava | - | Maccabi Tel Aviv | 0:0 | ||||
| 3. Round | 12/08/2021 | Maccabi Tel Aviv | - | Spartak Trnava | 1:0 |
Greece