| 4. Round | 27/03/2021 | Deportivo Merlo | - | Atlético San Miguel | 1:0 | ||||
| 5. Round | 04/04/2021 | Atlético San Miguel | - | Flandria | 1:1 | ||||
| 6. Round | 10/04/2021 | Cañuelas | - | Atlético San Miguel | 3:0 |  |
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| 10. Round | 08/05/2021 | Argentino de Quilmes | - | Atlético San Miguel | 2:1 |  |
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| 12. Round | 07/06/2021 | Colegiales de Munro | - | Atlético San Miguel | 0:1 | |
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| 13. Round | 15/06/2021 | Atlético San Miguel | - | Fénix | 3:2 | ||||
| 15. Round | 26/06/2021 | Atlético San Miguel | - | Villa San Carlos | 1:0 | ||||
| 16. Round | 03/07/2021 | Armenio | - | Atlético San Miguel | 1:1 | ||||
| 17. Round | 10/07/2021 | Atlético San Miguel | - | Comunicaciones de Buenos Aires | 2:0 |
Argentina