| 2. Round | 24/07/2021 | Talleres (RdE) | - | Atlético San Miguel | 1:1 | ||||
| 4. Round | 07/08/2021 | Atlético San Miguel | - | Deportivo Merlo | 1:0 | ||||
| 5. Round | 14/08/2021 | Flandria | - | Atlético San Miguel | 3:0 | ||||
| 6. Round | 21/08/2021 | Atlético San Miguel | - | Cañuelas | 0:2 | ||||
| 8. Round | 04/09/2021 | Atlético San Miguel | - | Sacachispas | 3:1 | ||||
| 9. Round | 13/09/2021 | Justo José de Urquiza | - | Atlético San Miguel | 1:2 | ||||
| 10. Round | 18/09/2021 | Atlético San Miguel | - | Argentino de Quilmes | 1:1 | ||||
| 11. Round | 25/09/2021 | CA Los Andes | - | Atlético San Miguel | 0:0 | ||||
| 12. Round | 02/10/2021 | Atlético San Miguel | - | Colegiales de Munro | 0:2 |  |
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| 13. Round | 09/10/2021 | Fénix | - | Atlético San Miguel | 1:2 |  |
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| 14. Round | 16/10/2021 | Atlético San Miguel | - | Defensores Unidos de Zárate | 1:1 | ||||
| 15. Round | 24/10/2021 | Villa San Carlos | - | Atlético San Miguel | 4:2 | |
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| 16. Round | 30/10/2021 | Atlético San Miguel | - | Armenio | 0:1 | ||||
| 17. Round | 06/11/2021 | Comunicaciones de Buenos Aires | - | Atlético San Miguel | 2:2 | |
Argentina