| 1. Round | 06/03/2021 | Villa San Carlos | - | Cañuelas | 1:1 | ||||
| 2. Round | 13/03/2021 | Acassuso | - | Villa San Carlos | 2:1 | ||||
| 5. Round | 04/04/2021 | Villa San Carlos | - | Argentino de Quilmes | 2:1 |  |
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| 6. Round | 12/04/2021 | CA Los Andes | - | Villa San Carlos | 1:0 | ||||
| 7. Round | 17/04/2021 | Villa San Carlos | - | Colegiales de Munro | 3:2 | |
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| 8. Round | 23/04/2021 | Fénix | - | Villa San Carlos | 2:1 | ||||
| 11. Round | 16/05/2021 | Armenio | - | Villa San Carlos | 1:1 | ||||
| 12. Round | 07/06/2021 | Villa San Carlos | - | Comunicaciones de Buenos Aires | 1:1 | ||||
| 13. Round | 15/06/2021 | UAI Urquiza | - | Villa San Carlos | 1:1 | |
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| 14. Round | 22/06/2021 | Villa San Carlos | - | Talleres (RdE) | 0:2 | ||||
| 15. Round | 26/06/2021 | Atlético San Miguel | - | Villa San Carlos | 1:0 | ||||
| 16. Round | 02/07/2021 | Villa San Carlos | - | Deportivo Merlo | 0:0 | ||||
| 17. Round | 09/07/2021 | Flandria | - | Villa San Carlos | 1:0 |
Argentina