| 2. Round | 23/07/2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 4. Round | 02/08/2021 | Argentinos Juniors II | - | Central Córdoba SdE II | 1:0 | ||||
| 6. Round | 13/08/2021 | Argentinos Juniors II | - | Banfield II | 0:0 | ||||
| 8. Round | 26/08/2021 | Argentinos Juniors II | - | Talleres de Córdoba II | 0:1 | ||||
| 10. Round | 03/09/2021 | Estudiantes II | - | Argentinos Juniors II | 2:0 | ||||
| 21. Round | 18/11/2021 | Argentinos Juniors II | - | Godoy Cruz II | 1:1 | ||||
| 22. Round | 25/11/2021 | Vélez Sarsfield II | - | Argentinos Juniors II | 1:1 | ||||
| 23. Round | 30/11/2021 | Argentinos Juniors II | - | Gimnasia de La Plata II | 1:2 | ||||
| 24. Round | 04/12/2021 | Aldosivi II | - | Argentinos Juniors II | 2:2 |
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