| 1. Round | 06/06/2022 | Defensa y Justicia | - | River Plate | 0:0 | ||||
| 2. Round | 12/06/2022 | River Plate | - | Atlético Tucumán | 0:0 | ||||
| 3. Round | 15/06/2022 | Colón de Santa Fe | - | River Plate | 1:0 | ||||
| 4. Round | 19/06/2022 | Unión de Santa Fe | - | River Plate | 1:5 | ||||
| 6. Round | 04/07/2022 | Huracán | - | River Plate | 3:2 |  |
|||
| 7. Round | 11/07/2022 | River Plate | - | Godoy Cruz | 0:2 |  |
|||
| 22. Round | 03/10/2022 | Argentinos Juniors | - | River Plate | 0:3 | ||||
| 24. Round | 10/10/2022 | Patronato de Paraná | - | River Plate | 0:1 | ||||
| 25. Round | 13/10/2022 | River Plate | - | Platense | 2:1 | |
|||
| 26. Round | 17/10/2022 | River Plate | - | Rosario Central | 1:2 | ||||
| 27. Round | 23/10/2022 | Racing Club | - | River Plate | 1:2 | |
Argentina
Portugal