| 8. Round | 27/06/2021 | Boston River | - | Liverpool | 1:1 | ||||
| 9. Round | 03/07/2021 | River Plate | - | Boston River | 1:1 |  |
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| 10. Round | 11/07/2021 | Boston River | - | Cerro Largo | 1:0 | ||||
| 11. Round | 16/07/2021 | Progreso | - | Boston River | 1:0 | ||||
| 12. Round | 31/07/2021 | Boston River | - | Sud América | 2:0 | ||||
| 13. Round | 09/08/2021 | Plaza Colonia | - | Boston River | 0:0 | ||||
| 14. Round | 16/08/2021 | Boston River | - | Fénix | 0:2 | ||||
| 15. Round | 21/08/2021 | Deportivo Maldonado | - | Boston River | 0:2 |
Uruguay