| 8. Round | 10/04/2022 | Boston River | - | Nacional | 0:6 | ||||
| 9. Round | 17/04/2022 | Nacional | - | River Plate | 1:1 | ||||
| 10. Round | 23/04/2022 | Cerro Largo | - | Nacional | 0:2 |  |
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| 11. Round | 09/05/2022 | Nacional | - | Fénix | 1:0 | |
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| 13. Round | 21/05/2022 | Nacional | - | Albion | 2:0 | ||||
| 14. Round | 29/05/2022 | Nacional | - | Cerrito | 3:0 | ||||
| 15. Round | 05/06/2022 | Danubio | - | Nacional | 2:1 |
Uruguay