| 1. Round | 09/08/2008 | Gimnasia de La Plata | - | Newell's Old Boys | 0:1 |  |
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| 3. Round | 23/08/2008 | Gimnasia de Jujuy | - | Newell's Old Boys | 1:0 | ||||
| 4. Round | 30/08/2008 | Colón de Santa Fe | - | Newell's Old Boys | 1:1 | ||||
| 2. Round | 25/09/2008 | Newell's Old Boys | - | Boca Juniors | 2:4 | ||||
| 8. Round | 28/09/2008 | Argentinos Juniors | - | Newell's Old Boys | 0:4 | ||||
| 9. Round | 05/10/2008 | Newell's Old Boys | - | Tigre | 2:0 |  |
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| 10. Round | 19/10/2008 | Godoy Cruz | - | Newell's Old Boys | 0:0 | ||||
| 11. Round | 25/10/2008 | Newell's Old Boys | - | Estudiantes | 1:1 | ||||
| 12. Round | 29/10/2008 | River Plate | - | Newell's Old Boys | 1:1 | ||||
| 13. Round | 02/11/2008 | Newell's Old Boys | - | Rosario Central | 1:0 | |
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| 14. Round | 07/11/2008 | Banfield | - | Newell's Old Boys | 2:1 | ||||
| 15. Round | 15/11/2008 | Newell's Old Boys | - | San Lorenzo | 3:3 | |
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| 16. Round | 21/11/2008 | Arsenal de Sarandí | - | Newell's Old Boys | 1:1 | ||||
| 17. Round | 30/11/2008 | Newell's Old Boys | - | Vélez Sarsfield | 1:0 | ||||
| 18. Round | 06/12/2008 | San Martín de Tucumán | - | Newell's Old Boys | 2:0 | |
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| 19. Round | 12/12/2008 | Newell's Old Boys | - | Racing Club | 3:0 |
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