| 11. Round | 10/09/2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Round | 17/09/2021 | Lanús II | - | Newell's Old Boys II | 0:2 | ||||
| 17. Round | 18/10/2021 | Newell's Old Boys II | - | Aldosivi II | 1:0 | ||||
| 19. Round | 29/10/2021 | Newell's Old Boys II | - | Independiente II | 1:0 | ||||
| 20. Round | 05/11/2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 | ||||
| 22. Round | 24/11/2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 | ||||
| 23. Round | 30/11/2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 24. Round | 06/12/2021 | Newell's Old Boys II | - | Banfield II | 2:0 |  |
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| 25. Round | 10/12/2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentina