| 1. Round | 16/07/2021 | Godoy Cruz II | - | Rosario Central II | 1:1 | ||||
| 2. Round | 23/07/2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 | ||||
| 3. Round | 27/07/2021 | Gimnasia de La Plata II | - | Rosario Central II | 4:3 |  |
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| 15. Round | 08/10/2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 16. Round | 13/10/2021 | Rosario Central II | - | Patronato de Paraná II | 2:1 | ||||
| 17. Round | 18/10/2021 | Platense II | - | Rosario Central II | 0:3 |
Argentina