| 1. Round | 16/07/2021 | Huracán II | - | Defensa y Justicia II | 3:0 | ||||
| 2. Round | 23/07/2021 | Defensa y Justicia II | - | Godoy Cruz II | 2:1 | ||||
| 3. Round | 26/07/2021 | Vélez Sarsfield II | - | Defensa y Justicia II | 0:0 | ||||
| 4. Round | 30/07/2021 | Defensa y Justicia II | - | Gimnasia de La Plata II | 0:5 | ||||
| 5. Round | 06/08/2021 | Aldosivi II | - | Defensa y Justicia II | 1:2 | ||||
| 6. Round | 13/08/2021 | Defensa y Justicia II | - | Sarmiento de Junín II | 3:0 | ||||
| 7. Round | 20/08/2021 | Independiente II | - | Defensa y Justicia II | 1:1 | ||||
| 11. Round | 09/09/2021 | Boca Juniors II | - | Defensa y Justicia II | 3:2 | ||||
| 14. Round | 01/10/2021 | Defensa y Justicia II | - | Talleres de Córdoba II | 2:2 | ||||
| 15. Round | 07/10/2021 | Argentinos Juniors II | - | Defensa y Justicia II | 0:0 | ||||
| 16. Round | 13/10/2021 | Defensa y Justicia II | - | Estudiantes II | 1:2 | ||||
| 19. Round | 28/10/2021 | Racing Club II | - | Defensa y Justicia II | 2:2 | ||||
| 25. Round | 09/12/2021 | Defensa y Justicia II | - | Lanús II | 2:0 |
Argentina