| 1. Round | 12/02/2000 | San Lorenzo | - | Newell's Old Boys | 1:0 |  |
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| 3. Round | 26/02/2000 | Rosario Central | - | Newell's Old Boys | 1:1 |  |
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| 4. Round | 04/03/2000 | Newell's Old Boys | - | Colón de Santa Fe | 3:3 | ||||
| 5. Round | 11/03/2000 | Estudiantes | - | Newell's Old Boys | 1:3 | ||||
| 6. Round | 18/03/2000 | Newell's Old Boys | - | Belgrano de Córdoba | 0:1 | ||||
| 7. Round | 01/04/2000 | Independiente | - | Newell's Old Boys | 1:2 | ||||
| 8. Round | 08/04/2000 | Newell's Old Boys | - | Lanús | 3:2 |  |
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| 9. Round | 10/04/2000 | Argentinos Juniors | - | Newell's Old Boys | 1:4 | ||||
| 10. Round | 15/04/2000 | Newell's Old Boys | - | Vélez Sarsfield | 1:1 | |
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| 11. Round | 13/05/2000 | Gimnasia de Jujuy | - | Newell's Old Boys | 3:0 | |
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| 12. Round | 19/05/2000 | Newell's Old Boys | - | River Plate | 2:4 | |
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| 13. Round | 26/05/2000 | Newell's Old Boys | - | Boca Juniors | 1:0 | ||||
| 14. Round | 09/06/2000 | Unión de Santa Fe | - | Newell's Old Boys | 1:0 | |
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| 16. Round | 23/06/2000 | Talleres de Córdoba | - | Newell's Old Boys | 1:3 | ||||
| 17. Round | 01/07/2000 | Newell's Old Boys | - | Racing Club | 2:0 | ||||
| 18. Round | 09/07/2000 | Chacarita Juniors | - | Newell's Old Boys | 0:1 | |
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