| 1. Round | 12/03/2021 | San Martín de San Juan | - | Atlético Rafaela | 4:2 |  |
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| 2. Round | 21/03/2021 | Guillermo Brown | - | San Martín de San Juan | 0:0 | ||||
| 3. Round | 29/03/2021 | San Martín de San Juan | - | Brown de Adrogué | 1:2 | ||||
| 4. Round | 04/04/2021 | San Martín de San Juan | - | All Boys | 0:2 | ||||
| 5. Round | 10/04/2021 | Villa Dálmine | - | San Martín de San Juan | 1:1 | ||||
| 6. Round | 18/04/2021 | San Martín de San Juan | - | San Telmo | 5:0 | |
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| 7. Round | 24/04/2021 | Defensores de Belgrano | - | San Martín de San Juan | 1:1 | |
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| 8. Round | 02/05/2021 | San Martín de San Juan | - | Ramón Santamarina | 0:2 | ||||
| 9. Round | 09/05/2021 | Almagro | - | San Martín de San Juan | 0:1 | ||||
| 10. Round | 16/05/2021 | San Martín de San Juan | - | Güemes de SdE | 1:2 |
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