| 1. Round | 15/08/2021 | Adana Demirspor | - | Fenerbahçe | 0:1 | ||||
| 2. Round | 20/08/2021 | Kayserispor | - | Adana Demirspor | 1:1 | ||||
| 3. Round | 27/08/2021 | Adana Demirspor | - | Konyaspor | 1:1 | ||||
| 4. Round | 11/09/2021 | Fatih Karagümrük | - | Adana Demirspor | 4:0 | ||||
| 5. Round | 18/09/2021 | Adana Demirspor | - | Çaykur Rizespor | 3:1 | ||||
| 7. Round | 25/09/2021 | Adana Demirspor | - | Gaziantep FK | 4:0 | ||||
| 8. Round | 01/10/2021 | Antalyaspor | - | Adana Demirspor | 1:2 | ||||
| 9. Round | 16/10/2021 | Adana Demirspor | - | Yeni Malatyaspor | 0:2 |  |
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| 16. Round | 12/12/2021 | Adana Demirspor | - | Giresunspor | 1:0 | ||||
| 21. Round | 15/01/2022 | Adana Demirspor | - | Kayserispor | 1:1 | ||||
| 22. Round | 18/01/2022 | Konyaspor | - | Adana Demirspor | 1:0 | ||||
| 23. Round | 22/01/2022 | Adana Demirspor | - | Fatih Karagümrük | 5:0 |
Argentina