| 1. Round | 17/01/2021 | Progreso | - | Montevideo City Torque | 0:0 | ||||
| 2. Round | 21/01/2021 | Plaza Colonia | - | Progreso | 0:1 |  |
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| 3. Round | 30/01/2021 | Progreso | - | Liverpool | 0:4 | |
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| 4. Round | 02/02/2021 | Progreso | - | Fénix | 0:1 | ||||
| 7. Round | 15/02/2021 | Danubio | - | Progreso | 0:1 | ||||
| 9. Round | 23/02/2021 | Boston River | - | Progreso | 2:3 | ||||
| 10. Round | 02/03/2021 | Progreso | - | Deportivo Maldonado | 1:1 | |
Uruguay