| 1. Round | 31/07/2022 | Danubio | - | Cerrito | 0:0 | ||||
| 2. Round | 07/08/2022 | Danubio | - | Deportivo Maldonado | 0:0 | ||||
| 3. Round | 13/08/2022 | Rentistas | - | Danubio | 0:1 | ||||
| 6. Round | 19/08/2022 | Danubio | - | Montevideo City Torque | 3:2 |  |
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| 5. Round | 28/08/2022 | Peñarol | - | Danubio | 1:1 | ||||
| 9. Round | 19/09/2022 | Boston River | - | Danubio | 0:1 | ||||
| 10. Round | 24/09/2022 | Danubio | - | River Plate | 3:0 | ||||
| 14. Round | 16/10/2022 | Danubio | - | Albion | 3:0 |
Uruguay