| 5. Round | 05/02/2023 | Santos Laguna | - | CF América | 2:2 |  |
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| 8. Round | 18/02/2023 | Atlético San Luis | - | Santos Laguna | 1:1 |  |
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| 7. Round | 24/02/2023 | Santos Laguna | - | Deportivo Toluca | 0:5 | ||||
| 9. Round | 27/02/2023 | Santos Laguna | - | Puebla FC | 3:2 | ||||
| 10. Round | 05/03/2023 | Deportivo Guadalajara | - | Santos Laguna | 2:0 | ||||
| 11. Round | 13/03/2023 | Santos Laguna | - | Club Tijuana | 3:2 | ||||
| 12. Round | 20/03/2023 | Club León | - | Santos Laguna | 4:1 |  |
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| 13. Round | 01/04/2023 | Club Necaxa | - | Santos Laguna | 0:0 | ||||
| 14. Round | 10/04/2023 | Santos Laguna | - | CF Pachuca | 1:4 | |
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| 15. Round | 17/04/2023 | CF Monterrey | - | Santos Laguna | 1:2 | |
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| 17. Round | 30/04/2023 | Cruz Azul | - | Santos Laguna | 3:2 |
Argentina