| 1. Round | 18/07/2021 | Huracán | - | Defensa y Justicia | 2:1 | ||||
| 2. Round | 23/07/2021 | Atlético Tucumán | - | Huracán | 1:0 |  |
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| 3. Round | 27/07/2021 | Huracán | - | Colón de Santa Fe | 1:1 | ||||
| 4. Round | 01/08/2021 | River Plate | - | Huracán | 1:1 | ||||
| 5. Round | 07/08/2021 | Huracán | - | Lanús | 0:1 | |
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| 6. Round | 14/08/2021 | Huracán | - | Unión de Santa Fe | 0:0 | ||||
| 7. Round | 21/08/2021 | Godoy Cruz | - | Huracán | 1:1 | |
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| 8. Round | 25/08/2021 | Huracán | - | Vélez Sarsfield | 1:1 | |
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| 9. Round | 28/08/2021 | Gimnasia de La Plata | - | Huracán | 0:0 | |
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| 11. Round | 13/09/2021 | Sarmiento de Junín | - | Huracán | 0:0 | ||||
| 12. Round | 19/09/2021 | Huracán | - | Independiente | 0:1 | ||||
| 13. Round | 28/09/2021 | Newell's Old Boys | - | Huracán | 0:1 | ||||
| 14. Round | 02/10/2021 | Huracán | - | Arsenal de Sarandí | 1:0 | ||||
| 15. Round | 08/10/2021 | Central Córdoba SdE | - | Huracán | 1:2 | |
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| 16. Round | 17/10/2021 | Huracán | - | Boca Juniors | 0:3 | ||||
| 17. Round | 20/10/2021 | Banfield | - | Huracán | 1:4 | |
Argentina