| 1. Round | 16/07/2021 | Vélez Sarsfield II | - | Racing Club II | 1:1 | ||||
| 3. Round | 27/07/2021 | Aldosivi II | - | Racing Club II | 2:0 |  |
|||
| 5. Round | 06/08/2021 | Independiente II | - | Racing Club II | 1:1 | ||||
| 6. Round | 16/08/2021 | Racing Club II | - | Newell's Old Boys II | 1:1 |  |
|||
| 7. Round | 20/08/2021 | Arsenal de Sarandí II | - | Racing Club II | 3:1 | ||||
| 8. Round | 24/08/2021 | Racing Club II | - | Central Córdoba SdE II | 3:0 | ||||
| 9. Round | 27/08/2021 | Boca Juniors II | - | Racing Club II | 4:0 | ||||
| 10. Round | 06/09/2021 | Racing Club II | - | Banfield II | 1:2 | ||||
| 11. Round | 10/09/2021 | San Lorenzo II | - | Racing Club II | 0:0 | ||||
| 12. Round | 20/09/2021 | Racing Club II | - | Talleres de Córdoba II | 2:0 | ||||
| 13. Round | 27/09/2021 | Argentinos Juniors II | - | Racing Club II | 2:1 | ||||
| 14. Round | 04/10/2021 | Racing Club II | - | Estudiantes II | 0:2 | ||||
| 16. Round | 14/10/2021 | Racing Club II | - | Platense II | 1:3 | ||||
| 20. Round | 05/11/2021 | Atlético Tucumán II | - | Racing Club II | 2:1 | ||||
| 23. Round | 27/11/2021 | Racing Club II | - | Lanús II | 1:1 | ||||
| 24. Round | 02/12/2021 | Huracán II | - | Racing Club II | 0:3 | ||||
| 25. Round | 11/12/2021 | Racing Club II | - | Godoy Cruz II | 2:1 |
Argentina