| 5. Round | 12/08/2018 | Libertad | - | Guaraní | 3:0 |  |
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| 6. Round | 19/08/2018 | Guaraní | - | Sol de América | 2:1 | ||||
| 7. Round | 25/08/2018 | 3 de Febrero | - | Guaraní | 2:1 | |
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| 8. Round | 02/09/2018 | Guaraní | - | Club Olimpia | 0:3 | ||||
| 9. Round | 09/09/2018 | General Díaz | - | Guaraní | 3:1 |  |
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| 13. Round | 07/10/2018 | Guaraní | - | Cerro Porteño | 0:1 | ||||
| 15. Round | 21/10/2018 | Club Nacional | - | Guaraní | 0:0 | ||||
| 20. Round | 23/11/2018 | Guaraní | - | General Díaz | 0:2 | |
Argentina
Chile