| 1. Round | 13/02/2022 | Estudiantes | - | Independiente | 2:1 | ||||
| 2. Round | 15/02/2022 | Independiente | - | Arsenal de Sarandí | 1:0 |  |
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| 3. Round | 20/02/2022 | Vélez Sarsfield | - | Independiente | 0:0 | ||||
| 4. Round | 27/02/2022 | Independiente | - | Boca Juniors | 2:2 | |
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| 5. Round | 07/03/2022 | Godoy Cruz | - | Independiente | 3:3 | ||||
| 6. Round | 15/03/2022 | Independiente | - | Central Córdoba SdE | 1:1 | ||||
| 7. Round | 19/03/2022 | Independiente | - | Racing Club | 1:2 | ||||
| 8. Round | 02/04/2022 | Barracas Central | - | Independiente | 0:1 | ||||
| 9. Round | 09/04/2022 | Independiente | - | Tigre | 1:1 | ||||
| 10. Round | 16/04/2022 | Colón de Santa Fe | - | Independiente | 2:2 | ||||
| 11. Round | 20/04/2022 | Independiente | - | Aldosivi | 1:1 | |
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| 12. Round | 23/04/2022 | Rosario Central | - | Independiente | 3:0 | |
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| 14. Round | 07/05/2022 | Independiente | - | Huracán | 3:0 |
Argentina
Italy 