| 1. Round | 04/06/2022 | Banfield | - | Newell's Old Boys | 1:2 | ||||
| 2. Round | 10/06/2022 | Newell's Old Boys | - | San Lorenzo | 0:0 | ||||
| 3. Round | 14/06/2022 | Talleres de Córdoba | - | Newell's Old Boys | 0:1 | ||||
| 4. Round | 21/06/2022 | Newell's Old Boys | - | Argentinos Juniors | 1:0 | ||||
| 5. Round | 25/06/2022 | Estudiantes | - | Newell's Old Boys | 0:2 | ||||
| 6. Round | 04/07/2022 | Newell's Old Boys | - | Patronato de Paraná | 2:2 |  |
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| 23. Round | 04/10/2022 | Newell's Old Boys | - | Arsenal de Sarandí | 0:0 |
Argentina
Italy