| 2. Round | 18/04/2021 | Juventud Unida de Gualeguaychú | - | Central Norte | 3:3 | ||||
| 5. Round | 09/05/2021 | Central Norte | - | Belgrano de San Francisco | 1:1 | ||||
| 7. Round | 07/06/2021 | Central Norte | - | Defensores Belgrano (VR) | 1:0 |  |
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| 8. Round | 20/06/2021 | Unión de Sunchales | - | Central Norte | 0:1 | ||||
| 9. Round | 27/06/2021 | Central Norte | - | Crucero del Norte | 4:1 |  |
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| 11. Round | 07/07/2021 | Chaco For Ever | - | Central Norte | 2:2 | |
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| 14. Round | 25/07/2021 | Central Norte | - | Douglas Haig | 0:0 | ||||
| 15. Round | 01/08/2021 | Sportivo Las Parejas | - | Central Norte | 2:1 | ||||
| 16. Round | 07/08/2021 | Boca Unidos | - | Central Norte | 2:3 | ||||
| 17. Round | 14/08/2021 | Central Norte | - | Juventud Unida de Gualeguaychú | 2:1 | |
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| 20. Round | 01/09/2021 | Belgrano de San Francisco | - | Central Norte | 0:2 | |
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| 21. Round | 05/09/2021 | Central Norte | - | Defensores de Pronunciamiento | 2:0 | |
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| 22. Round | 10/09/2021 | Defensores Belgrano (VR) | - | Central Norte | 2:0 | ||||
| 24. Round | 25/09/2021 | Crucero del Norte | - | Central Norte | 0:0 | ||||
| 26. Round | 03/10/2021 | Central Norte | - | Chaco For Ever | 2:0 | ||||
| 27. Round | 10/10/2021 | Racing de Córdoba | - | Central Norte | 1:1 |
Argentina