| 1. Round | 16/07/2021 | Huracán II | - | Defensa y Justicia II | 3:0 | ||||
| 7. Round | 20/08/2021 | Godoy Cruz II | - | Huracán II | 2:1 | ||||
| 8. Round | 25/08/2021 | Huracán II | - | Vélez Sarsfield II | 2:2 | ||||
| 9. Round | 30/08/2021 | Gimnasia de La Plata II | - | Huracán II | 2:0 | ||||
| 16. Round | 13/10/2021 | Huracán II | - | Boca Juniors II | 1:2 | ||||
| 17. Round | 18/10/2021 | Banfield II | - | Huracán II | 1:2 | ||||
| 24. Round | 02/12/2021 | Huracán II | - | Racing Club II | 0:3 |
Argentina