| 2. Round | 31/07/2021 | CF América [U18] | - | Club Necaxa [U18] | 2:3 | ||||
| 9. Round | 17/09/2021 | Club Necaxa [U18] | - | Atlas Guadalajara [U18] | 1:0 |  |
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| 10. Round | 23/09/2021 | CF Pachuca [U18] | - | Club Necaxa [U18] | 5:1 | ||||
| 11. Round | 28/09/2021 | Club Necaxa [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 12. Round | 03/10/2021 | UANL Tigres [U18] | - | Club Necaxa [U18] | 1:1 | ||||
| 14. Round | 20/10/2021 | Deportivo Toluca [U18] | - | Club Necaxa [U18] | 2:3 | ||||
| 15. Round | 23/10/2021 | CF Monterrey [U18] | - | Club Necaxa [U18] | 1:3 | ||||
| 16. Round | 29/10/2021 | Club Necaxa [U18] | - | Mazatlán FC [U18] | 3:0 | ||||
| 17. Round | 06/11/2021 | Club León [U18] | - | Club Necaxa [U18] | 3:2 |
Mexico