| 4. Round | 05/02/2022 | Club Tijuana [U20] | - | Pumas UNAM [U20] | 1:1 |  |
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| 5. Round | 11/02/2022 | Mazatlán FC [U20] | - | Club Tijuana [U20] | 0:2 | ||||
| 6. Round | 18/02/2022 | Club Tijuana [U20] | - | Club Necaxa [U20] | 2:1 | |
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| 7. Round | 25/02/2022 | Club Tijuana [U20] | - | Atlas Guadalajara [U20] | 2:1 | |
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| 8. Round | 01/03/2022 | Deportivo Toluca [U20] | - | Club Tijuana [U20] | 3:1 | ||||
| 10. Round | 12/03/2022 | Santos Laguna [U20] | - | Club Tijuana [U20] | 4:2 | ||||
| 11. Round | 18/03/2022 | Club Tijuana [U20] | - | FC Juárez [U20] | 1:1 | |
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| 12. Round | 03/04/2022 | UANL Tigres [U20] | - | Club Tijuana [U20] | 1:2 | ||||
| 9. Round | 06/04/2022 | Club Tijuana [U20] | - | Atlético San Luis [U20] | 2:1 | ||||
| 13. Round | 11/04/2022 | CF Pachuca [U20] | - | Club Tijuana [U20] | 0:0 | ||||
| 14. Round | 15/04/2022 | Club Tijuana [U20] | - | CF América [U20] | 4:0 | |
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| 16. Round | 24/04/2022 | Club Tijuana [U20] | - | Gallos Blancos [U20] | 1:0 |
Mexico