| 1. Round | 23/07/2021 | Club Necaxa [U20] | - | Santos Laguna [U20] | 3:0 | ||||
| 2. Round | 01/08/2021 | Santos Laguna [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 3. Round | 07/08/2021 | UANL Tigres [U20] | - | Santos Laguna [U20] | 1:1 |  |
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| 4. Round | 15/08/2021 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 1:2 |  |
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| 5. Round | 18/08/2021 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 3:1 | ||||
| 6. Round | 21/08/2021 | Club León [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 7. Round | 29/08/2021 | Santos Laguna [U20] | - | FC Juárez [U20] | 3:1 | ||||
| 14. Round | 15/09/2021 | CF América [U20] | - | Santos Laguna [U20] | 0:1 | ||||
| 9. Round | 19/09/2021 | Santos Laguna [U20] | - | Puebla FC [U20] | 4:2 | ||||
| 13. Round | 16/10/2021 | CF Pachuca [U20] | - | Santos Laguna [U20] | 2:2 | |
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| 15. Round | 24/10/2021 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 3:0 | ||||
| 16. Round | 30/10/2021 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 0:5 | |
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| 11. Round | 04/11/2021 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 2:1 | |
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| 17. Round | 07/11/2021 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 2:1 |
Mexico