| 3. Round | 23/01/2022 | Santos Laguna [U18] | - | Club Necaxa [U18] | 1:2 |  |
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| 4. Round | 05/02/2022 | Club Necaxa [U18] | - | CF Pachuca [U18] | 0:1 | ||||
| 8. Round | 01/03/2022 | Mazatlán FC [U18] | - | Club Necaxa [U18] | 2:0 | |
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| 9. Round | 04/03/2022 | Club Necaxa [U18] | - | Deportivo Toluca [U18] | 0:1 | ||||
| 10. Round | 11/03/2022 | Club Necaxa [U18] | - | Gallos Blancos [U18] | 2:0 | ||||
| 11. Round | 19/03/2022 | Pumas UNAM [U18] | - | Club Necaxa [U18] | 0:0 | ||||
| 12. Round | 02/04/2022 | Club Necaxa [U18] | - | CF América [U18] | 2:2 | ||||
| 14. Round | 15/04/2022 | Club Necaxa [U18] | - | Atlético San Luis [U18] | 1:2 | ||||
| 15. Round | 19/04/2022 | Club Necaxa [U18] | - | UANL Tigres [U18] | 2:0 | |
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| 16. Round | 22/04/2022 | Puebla FC [U18] | - | Club Necaxa [U18] | 1:4 |
Mexico