| 1. Round | 07/08/2010 | Newell's Old Boys | - | Estudiantes | 0:1 | ||||
| 3. Round | 21/08/2010 | Newell's Old Boys | - | Tigre | 2:0 |  |
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| 4. Round | 28/08/2010 | Huracán | - | Newell's Old Boys | 1:1 | ||||
| 5. Round | 05/09/2010 | Newell's Old Boys | - | Independiente | 1:1 | ||||
| 6. Round | 12/09/2010 | Argentinos Juniors | - | Newell's Old Boys | 1:2 | |
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| 8. Round | 26/09/2010 | Arsenal de Sarandí | - | Newell's Old Boys | 0:0 | ||||
| 13. Round | 06/11/2010 | Godoy Cruz | - | Newell's Old Boys | 0:0 | ||||
| 14. Round | 15/11/2010 | Newell's Old Boys | - | Racing Club | 0:2 | ||||
| 15. Round | 20/11/2010 | All Boys | - | Newell's Old Boys | 2:0 | ||||
| 16. Round | 28/11/2010 | Newell's Old Boys | - | Boca Juniors | 1:0 | |
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| 17. Round | 05/12/2010 | San Lorenzo | - | Newell's Old Boys | 0:0 | ||||
| 18. Round | 09/12/2010 | Newell's Old Boys | - | Olimpo de Bahía Blanca | 0:1 |
Argentina