| 7. Round | 20/08/2021 | San Lorenzo II | - | Argentinos Juniors II | 1:3 | ||||
| 9. Round | 30/08/2021 | San Lorenzo II | - | Patronato de Paraná II | 2:2 |  |
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| 10. Round | 05/09/2021 | Platense II | - | San Lorenzo II | 1:1 | ||||
| 12. Round | 17/09/2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 19. Round | 31/10/2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 20. Round | 05/11/2021 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | ||||
| 23. Round | 27/11/2021 | San Lorenzo II | - | Sarmiento de Junín II | 3:1 | ||||
| 24. Round | 06/12/2021 | Independiente II | - | San Lorenzo II | 1:0 |
Argentina