| 4. Round | 10/09/2021 | Everton FC U23 | - | Derby County U23 | 1:0 | ||||
| 5. Round | 20/09/2021 | Derby County U23 | - | West Ham United U23 | 3:1 | ||||
| 6. Round | 27/09/2021 | Tottenham Hotspur U23 | - | Derby County U23 | 3:1 |  |
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| 7. Round | 02/10/2021 | Manchester City U23 | - | Derby County U23 | 1:0 | ||||
| 8. Round | 16/10/2021 | Chelsea FC U23 | - | Derby County U23 | 2:0 |  |
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| 9. Round | 22/10/2021 | Derby County U23 | - | Crystal Palace U23 | 2:3 | |
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| 10. Round | 30/10/2021 | Liverpool FC U23 | - | Derby County U23 | 3:1 | ||||
| 11. Round | 05/11/2021 | Derby County U23 | - | Blackburn Rovers U23 | 6:0 | |
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| 12. Round | 19/11/2021 | Derby County U23 | - | Manchester United U23 | 1:1 | ||||
| 13. Round | 26/11/2021 | Arsenal FC U23 | - | Derby County U23 | 3:5 | |
England