| 1. Round | 29/07/2000 | Toulouse FC | - | SC Bastia | 0:1 | ||||
| 3. Round | 12/08/2000 | Toulouse FC | - | AS Saint-Étienne | 1:1 | ||||
| 4. Round | 19/08/2000 | RC Lens | - | Toulouse FC | 2:1 | ||||
| 5. Round | 26/08/2000 | Toulouse FC | - | FC Nantes | 1:1 | ||||
| 6. Round | 06/09/2000 | EA Guingamp | - | Toulouse FC | 2:1 |  |
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| 8. Round | 16/09/2000 | AS Monaco | - | Toulouse FC | 3:0 | ||||
| 10. Round | 30/09/2000 | Toulouse FC | - | AJ Auxerre | 0:1 | ||||
| 13. Round | 29/10/2000 | Lille OSC | - | Toulouse FC | 1:0 | ||||
| 14. Round | 04/11/2000 | Toulouse FC | - | RC Strasbourg | 0:0 | ||||
| 16. Round | 18/11/2000 | Toulouse FC | - | CS Sedan | 2:0 | ||||
| 18. Round | 29/11/2000 | Toulouse FC | - | ESTAC Troyes | 2:1 | ||||
| 19. Round | 02/12/2000 | AS Saint-Étienne | - | Toulouse FC | 1:0 | ||||
| 20. Round | 09/12/2000 | Toulouse FC | - | RC Lens | 1:0 | ||||
| 21. Round | 17/12/2000 | FC Nantes | - | Toulouse FC | 3:2 | ||||
| 22. Round | 21/12/2000 | Toulouse FC | - | EA Guingamp | 1:1 |  |
France