| 10. Round | 03/09/2021 | Defensa y Justicia | - | Central Córdoba SdE | 1:1 | ||||
| 12. Round | 21/09/2021 | Defensa y Justicia | - | Banfield | 0:0 | ||||
| 14. Round | 04/10/2021 | Defensa y Justicia | - | Talleres de Córdoba | 3:0 | ||||
| 16. Round | 16/10/2021 | Defensa y Justicia | - | Estudiantes | 2:1 | ||||
| 17. Round | 19/10/2021 | Patronato de Paraná | - | Defensa y Justicia | 3:3 | ||||
| 18. Round | 23/10/2021 | Defensa y Justicia | - | Platense | 2:1 | ||||
| 19. Round | 29/10/2021 | Racing Club | - | Defensa y Justicia | 1:2 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia | - | Rosario Central | 3:0 | ||||
| 21. Round | 18/11/2021 | Unión de Santa Fe | - | Defensa y Justicia | 2:3 | ||||
| 22. Round | 24/11/2021 | Atlético Tucumán | - | Defensa y Justicia | 0:4 | ||||
| 23. Round | 28/11/2021 | Defensa y Justicia | - | Colón de Santa Fe | 1:1 |  |
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| 24. Round | 06/12/2021 | River Plate | - | Defensa y Justicia | 2:3 | ||||
| 25. Round | 12/12/2021 | Defensa y Justicia | - | Lanús | 2:1 |
Argentina