| 1. Round | 16/07/2021 | Newell's Old Boys II | - | Talleres de Córdoba II | 2:1 | ||||
| 2. Round | 23/07/2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 4. Round | 30/07/2021 | Patronato de Paraná II | - | Newell's Old Boys II | 1:2 | ||||
| 5. Round | 06/08/2021 | Newell's Old Boys II | - | Platense II | 1:2 | ||||
| 7. Round | 20/08/2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 10. Round | 03/09/2021 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 13. Round | 24/09/2021 | Newell's Old Boys II | - | Huracán II | 2:0 | ||||
| 15. Round | 08/10/2021 | Newell's Old Boys II | - | Vélez Sarsfield II | 0:0 | ||||
| 16. Round | 14/10/2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 1:1 | ||||
| 17. Round | 18/10/2021 | Newell's Old Boys II | - | Aldosivi II | 1:0 | ||||
| 18. Round | 22/10/2021 | Sarmiento de Junín II | - | Newell's Old Boys II | 1:2 | ||||
| 21. Round | 17/11/2021 | Arsenal de Sarandí II | - | Newell's Old Boys II | 0:3 | ||||
| 25. Round | 10/12/2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentina