| 1. Round | 25/07/2021 | Club Tijuana [U20] | - | UANL Tigres [U20] | 1:1 | ||||
| 2. Round | 31/07/2021 | Club León [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 3. Round | 06/08/2021 | Club Tijuana [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 7. Round | 27/08/2021 | Club Tijuana [U20] | - | CF Monterrey [U20] | 1:0 | ||||
| 12. Round | 03/10/2021 | Club Tijuana [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 14. Round | 20/10/2021 | Club Tijuana [U20] | - | Deportivo Guadalajara [U20] | 1:2 | ||||
| 15. Round | 24/10/2021 | Pumas UNAM [U20] | - | Club Tijuana [U20] | 4:0 | ||||
| 16. Round | 28/10/2021 | Atlas Guadalajara [U20] | - | Club Tijuana [U20] | 1:1 | ||||
| 17. Round | 10/11/2021 | Club Tijuana [U20] | - | CF Pachuca [U20] | 2:1 |
USA