| 2. Round | 10/06/2021 | Rampla Juniors | - | Racing | 2:2 |  |
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| 3. Round | 20/06/2021 | Racing | - | Danubio | 2:1 | ||||
| 4. Round | 25/06/2021 | Rocha | - | Racing | 2:3 |  |
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| 5. Round | 01/07/2021 | Racing | - | CA Cerro | 0:0 | ||||
| 6. Round | 09/07/2021 | Defensor Sporting | - | Racing | 1:4 | ||||
| 7. Round | 15/07/2021 | Racing | - | Central Español | 1:0 | ||||
| 8. Round | 22/07/2021 | Atenas | - | Racing | 0:0 | ||||
| 9. Round | 29/07/2021 | Albion | - | Racing | 0:0 | ||||
| 10. Round | 07/08/2021 | Racing | - | Villa Teresa | 2:0 | ||||
| 11. Round | 13/08/2021 | Juventud de Las Piedras | - | Racing | 2:0 | ||||
| 12. Round | 16/09/2021 | Uruguay Montevideo | - | Racing | 1:2 | ||||
| 14. Round | 29/09/2021 | Danubio | - | Racing | 2:0 | ||||
| 17. Round | 20/10/2021 | Racing | - | Defensor Sporting | 0:1 | ||||
| 18. Round | 28/10/2021 | Central Español | - | Racing | 1:1 | ||||
| 19. Round | 02/11/2021 | Racing | - | Atenas | 0:0 | ||||
| 20. Round | 09/11/2021 | Racing | - | Albion | 1:1 | ||||
| 21. Round | 17/11/2021 | Villa Teresa | - | Racing | 0:0 | ||||
| 22. Round | 23/11/2021 | Racing | - | Juventud de Las Piedras | 3:1 |
Uruguay