5. Round | 06/08/2021 | Unión de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
6. Round | 13/08/2021 | Talleres de Córdoba II | - | San Lorenzo II | 1:0 | ||||
7. Round | 20/08/2021 | San Lorenzo II | - | Argentinos Juniors II | 1:3 | ||||
11. Round | 10/09/2021 | San Lorenzo II | - | Racing Club II | 0:0 | ||||
12. Round | 17/09/2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
13. Round | 24/09/2021 | San Lorenzo II | - | Defensa y Justicia II | 0:2 | ||||
24. Round | 06/12/2021 | Independiente II | - | San Lorenzo II | 1:0 | ||||
25. Round | 10/12/2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |